How does occupation affect Alzheimers risk?

Here are three tidbits that I picked up about this on a very preliminary read-through:

  • Most studies find no large effect of occupation per se on AD risk, and most of the effect that is there appears to be mediated by education (see here)
  • Low job autonomy (which has been previously associated with higher levels of job stress) is associated with an increased risk of AD (n = 900 in Sweden; HR = 2.2; see here)
  • At least one case report suggests that increased exposure to aluminum in one’s occupation can predispose to an increased risk of AD. Larger studies would be needed to endow this finding with more confidence (see here)