Tau imaging levels correlate with worse memory in living AD patients

Gabrielle Strobel at the inimitable AlzForum has a nice article about how tau imaging levels correlate more strongly with memory deficits than amyloid imaging levels in patients with AD, based on recent conference data.

In med school (read: First Aid for the USMLE S1, 2014), we also learned that tau levels correlate more strongly with memory deficits, but that was based on post-mortem neuropath, which is slightly more likely to be confounded.

I await the actual publications to get a sense of what the correlation numbers are. In postmortem neuropath exam, the correlations (r^2) are 0.74 for tau tangles and 0.50 for amyloid plaques with final MMSE, respectively.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560290/

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